Oracle Corporation announces the end of Error Correction Support for Oracle Database version(s) 8.1.7 (8i) & 8.1.7.x (8i) on the following platform(s): Microsoft Windows XP, Microsoft Windows 2000, Linux x86, HP-UX PA-RISC, IBM OS/390 (z/OS) version(s) ALL - OSDI, excluding MPM, Microsoft Windows 98, HP Tru64 UNIX, HP Alpha OpenVMS, Solaris Operating System (x86), IBM AIX-Based Systems version(s) 5L, Fujitsu-Siemens BS2000/OSD, Solaris Operating System (SPARC), Microsoft Windows NT for Intel, effective 3. In hypertensive subjects and SHR, a single dose lowers arterial blood pressure for substantial periods of time.Product Obsolescence / Desupport Information: In conclusion, N is a potent and selective beta 1-adrenergic blocking agent with an interesting hemodynamic profile. In healthy volunteers N (5 mg) lowered systemic vascular resistance during daily oral treatment and did not negatively affect left ventricular function. In contrast to other beta-adrenergic antagonists, N acutely lowered arterial blood pressure in SHR (1.25 mg.kg-1 i.p.) and in hypertensive patients (1 oral dose of 5 mg) for several hours. In dogs, as compared with propranolol, N (0.025 and 0.01 mg.kg-1 i.v.) increased cardiac output and stroke volume, lowered systemic vascular resistance, and had no significant effect on the variables related to left ventricular contraction. In dogs-similarly with atenolol-N was more potent in blocking the isoprenaline (I)-induced increases in left ventricular performance than the I-induced decrease in arterial pressure. The selectivity for the beta 1-adrenergic receptor was higher for N than for any of the reference compounds. In vitro, N was found to be a potent antagonist of beta 1-adrenergic receptors (A2 value, 5.8 X 10(-9) M) and only a weak beta 2-adrenergic antagonist (A2 value, 1.7 X 10(-6) M). The pharmacological profile of nebivolol (N), a chemically novel beta-adrenergic antagonist, was assessed in investigations on isolated tissues, awake spontaneously hypertensive rats (SHR), closed-chest anesthetized dogs, and humans.
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